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7,8-Dihydroxyflavone is a compound with biological effects. After intraperitoneal injection or oral administration to mice, 7,8-Dihydroxyflavone can cross the blood-brain barrier and activate TrkB and its downstream PI3K/Akt and MAPK. 7,8-DHF promotes the viability of cortical neurons and reduces their apoptosis during traumatic brain injury. Administration of 7,8-DHF 3 hours after injury, 7,8-DHF can reduce tissue damage through PI3K/Akt signaling pathway. The treatment of 7,8-DHF did not induce any obvious toxic effects in mice, and long-term administration was not toxic to mice. 7,8-DHF has a strong therapeutic effect on Alzheimer’s disease, and can inhibit obesity by activating muscle TrkB.