7,8-Dihydroxyflavone Hydrate

7,8-Dihydroxyflavone is a compound with biological effects. After intraperitoneal injection or oral administration to mice, 7,8-Dihydroxyflavone can cross the blood-brain barrier and activate TrkB and its downstream PI3K/Akt and MAPK. 7,8-DHF promotes the viability of cortical neurons and reduces their apoptosis during traumatic brain injury. Administration of 7,8-DHF 3 hours after injury, 7,8-DHF can reduce tissue damage through PI3K/Akt signaling pathway. The treatment of 7,8-DHF did not induce any obvious toxic effects in mice, and long-term administration was not toxic to mice. 7,8-DHF has a strong therapeutic effect on Alzheimer’s disease, and can inhibit obesity by activating muscle TrkB.

Product name: 7,8-Dihydroxyflavone Hydrate

Other name：7,8-dihydroxy-2-phenylchromen-4-one;7,8-Dihydroxyflavone Hydrate;

7,8-Dihydroxy-2-phenyl-4H-chromen-4-one;7,8-Dihydroxyflavone;

CAS Number: 38183-03-8

Molecular Formula: C15H10O4 · xH2O

Molecular Weight: 254.24 (anhydrous basis)

Purity: 98%

Appearance: Light yellow crystalline powder

Package: 1kg/bag

Use: nootropics

1. 7,8-dihydroxyflavone has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer’s disease, cognitive deficits in schizophrenia, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome.

2. 7,8-dihydroxyflavone also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents.

3. 7,8-dihydroxyflavone possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against
glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.